Capturing a Dynamic Chaperone–Substrate Interaction Using NMR-Informed Molecular Modeling
نویسندگان
چکیده
منابع مشابه
Capturing a Dynamic Chaperone-Substrate Interaction Using NMR-Informed Molecular Modeling.
Chaperones maintain a healthy proteome by preventing aggregation and by aiding in protein folding. Precisely how chaperones influence the conformational properties of their substrates, however, remains unclear. To achieve a detailed description of dynamic chaperone-substrate interactions, we fused site-specific NMR information with coarse-grained simulations. Our model system is the binding and...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2016
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.6b02382